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首頁 > 技術文章 > Life Diagnostics授權代理-上海起發

Life Diagnostics授權代理-上海起發

 更新時間:2023-12-07 點擊量:89

Life Diagnostics生產ELISA試劑盒、SPARCL™試劑盒、用于臨床前研究和獸醫診斷的純化生物標志物和抗體。Life Diagnostics的專業領域包括心血管、急性期、免疫毒性和免疫學生物標志物,涉及的物種包括老鼠、大鼠、兔子、貓、狗、豬、牛、猴子和雞。此外,Life Diagnostics還開發了抗PEG單克隆抗體和ELISA試劑盒,用于檢測PEG、mPEG化蛋白和抗PEG抗體。Life Diagnostics公司一直致力于為客戶提供高質量的產品和優質的服務,贏得了廣泛的贊譽和信任。

主要產品線

一、SPARCL試劑盒

SPARCL™(空間近距分析試劑捕獲發光)檢測使用兩種特定的抗體;一種與HRP結合,另一種與二氫化吖啶結合,一種化學發光底物。當HRP二氫化吖啶結合的抗體與它們的靶生物標志物結合時,加入過氧化氫(觸發溶液)后,HRP催化氧化鄰近二氫化吖啶分子,導致與生物標志物濃度成比例的化學發光。遠離HRP二氫化吖啶分子不被氧化,因此不產生發光。這一原理可以開發一系列快速敏感的均相免疫分析方法。

典型的SPARCL™檢測不需要洗滌步驟,只需一次孵育,從開始到結束大約需要45分鐘。ELISA需要1-4次孵育,1-3次洗滌步驟,需要2-4+小時。SPARCL™試劑盒需要一個能夠同時加樣和測量的光度計。Life Diagnostics提供一系列的SPARCL™檢測試劑盒。

圖片1.jpg

SPARCLELISA的優秀替代品

–簡單發光免疫測定

–單次培養30分鐘

–無清洗步驟

–高靈敏度

–高吞吐量

參考文獻

1. Baka R, et al. Quantitative proteomics of cerebrospinal fluid using tandem mass tags in dogs with recurrent epileptic sezures. J Proteomics 231:1039777 (2021)

2. Kules J, et al. The plasma proteome and the acute phase protein response in canine pyometra. J Proteomics 223:103817 (2020)

3. Liu M, et al. Cardiovascular-renal axis disorder and the acute-phase proteins in cats with congestive heart failure caused by primary cardiomyopathy. J Vet Intern Med. 34(3):1078-1090 (2020)

4. Dalanezi FM, et al. Concentrations of acute phase proteins in milk from cows with clinical mastitis caused by different pathogens. Pathogens 9(9):706 (2020)

5. Boulay I, et.al. SPARCL: Use of a novel technology in validation of a Non-human primate and rat cardiac troponin-I assay in serum. CiToxLAB, 2016

6. Boulay I, et.al. SPARCL: Use of a Novel Technology in Validation of a Non-Human Primate C-Reactive Protein Assay in Serum. CiToxLAB. 2016

部分產品信息

貨號

產品名稱

規格

AFP-SP-4

Dog Alpha-fetoprotein

96-well

AGP-SP-11

Cow AGP

96-well

AGP-SP-2

Rat AGP

96-well

AGP-SP-5

Chicken AGP

96-well

AGP-SP-8

Cat AGP

96-well

CER-SP-4

Dog Ceruloplasmin

96-well

CYSC-SP-2

Rat Cystatin-C

96-well

HFABP-SP-20

Human H-FABP

96-well

IGG1-SP-1

Mouse IgG1

96-well

IGG-SP-1

Mouse IgG

96-well

MPEG-SP

mPEG

96-well

MYO-SP-1

Mouse Myoglobin

96-well

MYO-SP-2

Rat Myoglobin

96-well

MYO-SP-3

Monkey Myoglobin

96-well

PEG-SP

PEG

96-well

TK1-SP-20

Human Thymidine Kinase 1

96-well

二、ELISA試劑盒

KLH、抗SRBC、抗破傷風毒素、抗DNP和抗TNPIgMIgG被用作免疫毒性的生物標志物。Life Diagnostics為小鼠、大鼠、雞、猴子和人類生產這些生物標志物的ELISA試劑盒。

圖片2.jpg

使用Life Diagnostics ELISA試劑盒發表的部分文獻

1. Lo J, et al. Immature dendritic cell therapy confers durable immune modulation in an antigen-dependent and antigen-independent manner in nonobese diabetic mice. Journal of Immunology Research. Volume 2018 Article ID 5463879 (2108) [Mouse anti-KLH IgG & IgM]

2. Ksiazek A and Konarzewski M. Heat dissipation does not suppress an immune response in laboratory mice divergently selected for basal metabolic rate (BMR). Journal of Experimental Biology. 219:1542-1551 (2016) [Mouse anti-KLH IgG & IgM]

3. Tan X, et al. Immunotoxicological evaluation of genetically modified rice expressing Cry1Ab/AcProtein (TT51-1) by a 6-month feeding study on cynomolgus monkeys. PLoSONE 11(9):e0163879.doi:10.1371/journal.pone.0163879 (2016) [Monkey anti-KLH IgG & IgM]

4. Ma H, Wan S, and Xia C-Q. Immunosuppressive CD11b+Ly6Chi monocytes in pristane-induced lupus mouse model. Journal of Leukocyte Biology 99:1121 (2016). [Mouse anti-KLH IgG]

5. Nixon AE, et al. Fully human monoclonal antibody inhibitors of the neonatal Fc receptor reduce circulating IgG in non-human primates. Frontiers in Immunology. Volume 6, Article 176. (2015) [Monkey anti-tetanus toxoid & anti-KLH IgG & IgM]

6. Bernett MJ, et al. Immune suppression in cynomolgus monkeys by XPro9523. (2013) https://doi.org/10.4161/mabs.23976 [Monkey anti-KLH IgG & IgM]

7. Nain S and Smits JEG. Pathological, immunological and biochemical markers of subchronic arsenic toxicity in rats. Environmental Toxicology. (2010) http://onlinelibrary.wiley.com/doi/10.1002/tox.20635/abstract [Rat anti-KLH IgG & IgM]

8. Betz BC, Jordan-Williams KL, Wang C, Kang SG, Liao J, Logan MR, Kim CH and Taparowsky EJ. Batf coordinates multiple aspects of B and T cell function required for normal antibody responses. J. Exp. Med. 207(5):933-942 (2011) [Mouse anti-SRBC IgG & IgM] http://jem.rupress.org/content/207/5/933.full.pdf+html

9. Schaffer BS, Grayson MH and Wortham JM, et al. Immune competency of a hairless mouse strain for improved preclinical studies in genetically engineered mice. Mol. Cancer Ther. 9:2354-2364 (2010) [Mouse anti-KLH IgG & IgM] http://mct.aacrjournals.org/content/9/8/2354.full.pdf+html

10. Efanov A, Zanesi N, NazaryanN, Santanam U, Palmarchuck A Croce CM and Pekarsky Y. CD5+CD23+ leukemic cell populations in TCL1 transgenic mice show significantly increased proliferation and Akt phosphorylation. Leukemia 24:970-975 (2010) [Mouse anti-SRBC IgM]

部分產品信息

貨號

產品名稱

規格

KLHG-1

Mouse Anti-KLH IgG ELISA

96-well

KLHM-1

Mouse Anti-KLH IgM ELISA

96-well

KLHG-20

Human Anti-KLH IgG ELISA

96-well

KLHM-20

Human Anti-KLH IgM ELISA

96-well

TTG-2

Rat Anti-Tetanus Toxoid IgG ELISA

96-well

TTM-2

Rat Anti-Tetanus Toxoid IgM ELISA

96-well

DNPG-1

Mouse Anti-DNP IgG ELISA

96-well

DNPM-1

Mouse Anti-DNP IgM ELISA

96-well

TNPG-1

Mouse Anti-TNP IgG ELISA

96-well

TNPM-1

Mouse Anti-TNP IgM ELISA

96-well

SRBCG-5

Chicken Anti-SRBC IgG ELISA

96-well

SRBCM-5

Chicken Anti-SRBC IgM ELISA

96-well

三、蛋白

Life Diagnostics提供alpha-1-acid glycoprotein、CRP、haptoglobin、SAA急性期生物標志物、troponin-I、myoglobin、FABP心血管生物標志物、免疫球蛋白、Haptoglobin、Gc-Globulin肝臟生物標志物、Troponin-I骨骼肌生物標志物等系列產品,用于臨床前研究研究和診斷分析開發。

圖片3.jpg

部分產品信息

貨號

產品名稱

規格

8340

Bovine (Cow) alpha-1-acid glycoprotein

1 mg

9060

CAT LRG1

100 μg

8160

Cat Haptoglobin

1 mg

EXFABP-5-0.05

Chicken EX-FABP

0.05 mg

9005

Dog Serum Amyloid A (SAA)

0.1 mg

8356

Rabbit a-1-Acid glycoprotein

0.1 mg

20110

Mouse L-FABP

0.1 mg

20220

Rat Gc-Globulin

0.1 mg

HAPT-2

Rat Haptoglobin

1 mg

3610

Chicken Skeletal Muscle Troponin-I

0.1 mg

3410

Sheep Skeletal Muscle Troponin-I

0.1 mg

四、PEG相關產品

聚乙二醇(PEG)鏈連接到治療性抗體和酶上,可以增加生物制劑的循環半衰期。Life Diagnostics生產單克隆抗體和ELISA試劑盒,用于檢測PEG和甲氧基-PEG化蛋白。此外,Life Diagnostics還提供用于檢測小鼠、大鼠和猴子體內抗PEG IgGIgMELISA試劑盒。

部分產品信息

貨號

產品名稱

規格

5D6-3

Anti-methoxy-PEG Monoclonal, Clone 5D6-3

100 μg

1D9-6

Anti-PEG Monoclonal, Clone 1D9-6

100 μg

PEGPAB-01

Anti-PEG Rabbit Polyclonal IgG Antibody

100 μg

PEGM-3

Monkey Anti-PEG IgM ELISA

96-well

PEGM-20

Human Anti-PEG IgM ELISA

96-well

PEGM-10

Rabbit Anti-PEG IgM ELISA

96-well

PEGG-3

Monkey Anti-PEG IgG ELISA

96-well

PEGG-20

Human Anti-PEG IgG ELISA

96-well

PEGG-10

Rabbit Anti-PEG IgG ELISA

96-well

PEGM-2

Rat Anti-PEG IgM ELISA

96-well

PEGM-1

Mouse Anti-PEG IgM ELISA

96-well

PBSA-00

Multi PEGylated BSA

1 mg

PBSA-01P

Mono-PEGylated BSA (pentanoic acid-PEG, 20 kDa)

100 μg

五、抗體

Life Diagnostics提供alpha-1-acid glycoprotein急性期生物標志物、troponin-I、myoglobin、FABP等心血管生物標志物、免疫球蛋白、Haptoglobin、Gc-Globulin肝臟生物標志物、Troponin-I骨骼肌生物標志物等蛋白抗體以及一系列二抗產品。

圖片5.jpg

部分產品信息

貨號

產品名稱

規格

IGE-4-13H5

Anti-Dog IgE Monoclonal

1 mg

IGE-4-4D1

Anti-Dog IgE Monoclonal

1 mg

IGM-23-12B9

Anti-Trout IgM Monoclonal

1 mg

IGM-23-2E7

Anti-Trout IgM Monoclonal

1 mg

10C2-9

Monoclonal Anti Monkey IgG

1 mg

6D11-2

Monoclonal Anti Monkey IgG

1 mg

2C11-1-5

Monoclonal Anti Monkey IgM

1 mg

7E8-1-13

Monoclonal Anti Monkey IgM

1 mg

AGP-08-4F57

Anti-cat alpha-1-acid glycoprotein

1 mg

下圖為Life Diagnostics公司授權上海起發在中國區域的代理的授權書。

Life Diagnostics熱賣產品

貨號

產品名稱

規格

品牌

CRP-3

Monkey C-Reactive Protein (CRP) ELISA kit

96 well

Life Diagnostics

KLHM-3

Monkey Anti-KLH IgM ELISA kit

96 well

Life Diagnostics

KLHG-3-INT

Monkey Anti-KLH IgG ELISA kit for export

96 well

Life Diagnostics

KLHM-2

RAT ANTI-KLH IGM ELISA

96 well

Life Diagnostics

KLHG-2

Rat Anti-KLH IgG ELISA

96 well

Life Diagnostics

1D9-6/MG

ANTI-PEG MONOCLONAL, CLONE 1D9-6

0.1mg

Life Diagnostics

PEGG-20

HUMAN ANTI-PEG IGG ELISA

96 well

Life Diagnostics

IGG-20

Human IgG ELISA

96 well

Life Diagnostics

5H4-2-1mg

ANTI-METHOXY PEG

1 mg

Life Diagnostics

1D9-6-1mg

ANTI-PEG MONOCLONAL, CLONE

1 mg

Life Diagnostics

PBSA-00

Multi PEGylated BSA - BSA with multiple covalently attached 20 kDa mPEG chains

1 mg

Life Diagnostics

PBAS-00-550-1mg

Multi PEGylated BSA

1 mg

Life Diagnostics

PBAS-00-550-10mg

Multi PEGylated BSA

10 mg

Life Diagnostics

5D6-3-0.1mg

ANTI-METHOXY PEG

0.1 mg

Life Diagnostics

KLHM-20

HUMAN ANTI-KLH IGM ELISA

96 well

Life Diagnostics

5D6-3-1mg

ANTI-METHOXY PEG

1 mg

Life Diagnostics

5H4-2-0.1mg

ANTI-METHOXY PEG

0.1 mg

Life Diagnostics

KLHG-20

Human Anti-KLH IgG ELISA

96 well

Life Diagnostics

CLUS-1

Mouse Clusterin ELISA kit

96 well

Life Diagnostics

8511-0.1mg

Rat a-2-Macroglobulin

0.1 mg

Life Diagnostics

IGE-3

MONKEY IGE ELISA

96 well

Life Diagnostics

IGE-2

Rat IgE

96 well

Life Diagnostics

CTNI-3-US

MONKEY CARDIAC TROPONIN-I ELISA

96 well

Life Diagnostics

CTNI-1-US

Mouse cTnI, (serum/plasma) ELISA kit

96 well

Life Diagnostics

CTNI-1-HS

Mouse cTnI (serum) ELISA kit

96 well

Life Diagnostics

crp-sp-20

HUMAN CRP SPARCL™ ASSAY

96 well

Life Diagnostics

CRP-2

Rat C-Reactive Protein (CRP) ELISA kit

96 well

Life Diagnostics

8511-PT1MG

RAT ALPHA-2-MACROGLOBULIN, 8511

0.1 mg

Life Diagnostics

作為Life Diagnostics中國區域總代理,上海起發將為中國客戶提供全面的Life Diagnostics產品。歡迎大家隨時聯系我們?。?!

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